Takashi Matozaki Selected Research

Proteins (Proteins, Gene)

1/2022	Anticancer efficacy of monotherapy with antibodies to SIRPα/SIRPβ1 mediated by induction of antitumorigenic macrophages.
12/2019	Deletion of SIRPα (signal regulatory protein-α) promotes phagocytic clearance of myelin debris in Wallerian degeneration, axon regeneration, and recovery from nerve injury.
8/2018	CD47-signal regulatory protein α signaling system and its application to cancer immunotherapy.
1/2017	Prion pathogenesis is unaltered in the absence of SIRPα-mediated "don't-eat-me" signaling.
1/2017	Microvillus-Specific Protein Tyrosine Phosphatase SAP-1 Plays a Role in Regulating the Intestinal Paracellular Transport of Macromolecules.
1/2014	Signal regulatory protein alpha is present in several neutrophil granule populations and is rapidly mobilized to the cell surface to negatively fine-tune neutrophil accumulation in inflammation.
11/2011	CD47-signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction.
5/2010	Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn.
12/2009	Signal regulatory protein-beta1: a microglial modulator of phagocytosis in Alzheimer's disease.
12/2009	Inhibitory regulation of osteoclast bone resorption by signal regulatory protein alpha.

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Takashi Matozaki Research Topics

Disease

14	Neoplasms (Cancer) 01/2023 - 11/2011
4	Colitis 01/2020 - 12/2010
3	Carcinogenesis 01/2023 - 03/2009
3	Stomach Neoplasms (Stomach Cancer) 05/2010 - 09/2002
2	Inflammation (Inflammations) 11/2023 - 01/2014
2	Tuberous Sclerosis (Bourneville's Disease) 01/2020 - 04/2019
2	Neoplasm Metastasis (Metastasis) 01/2020 - 05/2007
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2018 - 08/2015
2	Breast Neoplasms (Breast Cancer) 01/2017 - 11/2011
2	Insulin Resistance 09/2014 - 11/2008
2	Hypothermia 11/2012 - 06/2012
2	Contact Dermatitis (Eczema, Contact) 11/2008 - 04/2006
1	Liver Cirrhosis (Hepatic Cirrhosis) 11/2023
1	Non-alcoholic Fatty Liver Disease 11/2023
1	Cadaver (Cadavers) 11/2023
1	Fibrosis (Cirrhosis) 11/2023
1	Langerhans-Cell Histiocytosis (Histiocytosis, Langerhans Cell) 05/2023
1	Lymphoma (Lymphomas) 01/2023
1	Nephritis 07/2020
1	Atherosclerosis 01/2020
1	Graft vs Host Disease (Graft-Versus-Host Disease) 01/2020
1	Infections 01/2020
1	Wallerian Degeneration 12/2019
1	Demyelinating Diseases (Demyelinating Disease) 01/2019
1	Colonic Neoplasms (Colon Cancer) 11/2018
1	Burkitt Lymphoma (Burkitt's Lymphoma) 05/2018
1	Scrapie 01/2017
1	Prion Diseases (Transmissible Spongiform Encephalopathies) 01/2017
1	Hyperplasia 11/2016
1	Obesity 09/2014
1	Hyperlipidemias (Hyperlipidemia) 09/2014
1	Albuminuria 09/2013
1	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 09/2013
1	Glomerulonephritis 06/2012
1	Splenomegaly 06/2012
1	Starvation 06/2012
1	Interstitial Lung Diseases (Interstitial Lung Disease) 06/2012
1	Brain Diseases (Brain Disorder) 12/2011
1	Bone Resorption 12/2009
1	Alzheimer Disease (Alzheimer's Disease) 12/2009

Drug/Important Bio-Agent (IBA)

15	Proteins (Proteins, Gene)FDA Link 01/2022 - 09/2002
6	AntibodiesIBA 01/2020 - 06/2003
5	Protein Tyrosine PhosphatasesIBA 08/2015 - 09/2002
5	Tyrosine (L-Tyrosine)FDA Link 06/2012 - 09/2002
3	CytokinesIBA 01/2023 - 08/2015
3	Rituximab (Mabthera)FDA Link 01/2023 - 05/2018
3	src-Family KinasesIBA 01/2021 - 11/2016
3	Peptides (Polypeptides)IBA 01/2020 - 07/2007
2	LipidsIBA 11/2023 - 09/2014
2	ChemokinesIBA 01/2020 - 08/2015
2	Mechanistic Target of Rapamycin Complex 1IBA 01/2020 - 04/2019
2	Monoclonal AntibodiesIBA 11/2018 - 11/2011
2	Fc Receptors (Fc Receptor)IBA 01/2018 - 04/2004
1	CholesterolIBA 11/2023
1	Cre recombinaseIBA 01/2023
1	Biomarkers (Surrogate Marker)IBA 01/2023
1	villinIBA 01/2023
1	Amino Acid Transport Systems (Amino Acid Transporter)IBA 01/2023
1	Immune Checkpoint InhibitorsIBA 01/2023
1	CateninsIBA 01/2023
1	AntigensIBA 04/2022
1	chenodeoxycholate sulfate conjugate (CDCS)IBA 04/2022
1	Collagenases (Collagenase)FDA Link 07/2020
1	Antiviral Agents (Antivirals)IBA 01/2020
1	Explosive Agents (Explosives)IBA 01/2020
1	Dextran SulfateIBA 01/2020
1	CuprizoneIBA 01/2019
1	cytidylyl-(3'-5')-cytidine (CpC)IBA 11/2018
1	Recombinant ProteinsIBA 08/2018
1	Neoplasm Antigens (Tumor Antigens)IBA 05/2018
1	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2018
1	Dextrans (Dextran)FDA Link 01/2018
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2017
1	Prion ProteinsIBA 01/2017
1	PrionsIBA 01/2017
1	Messenger RNA (mRNA)IBA 01/2017
1	InterleukinsIBA 08/2015
1	Leptin ReceptorsIBA 09/2014
1	AMP-Activated Protein KinasesIBA 09/2014
1	LeptinIBA 09/2014
1	Doxorubicin (Adriamycin)FDA LinkGeneric 09/2013
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 11/2012
1	ElementsIBA 11/2012
1	PicrotoxinIBA 06/2012
1	AutoantibodiesIBA 06/2012
1	Ethanol (Ethyl Alcohol)IBA 06/2012
1	Trastuzumab (Herceptin)FDA Link 11/2011
1	Interleukin-10 (Interleukin 10)IBA 12/2010
1	Interleukin-17 (Interleukin 17)IBA 12/2010
1	6-pyruvoyltetrahydropterin synthase (PTPS)IBA 05/2010
1	Class 3 Receptor-Like Protein Tyrosine PhosphatasesIBA 05/2010
1	Amyloid (Amyloid Fibrils)IBA 12/2009
1	DinitrofluorobenzeneIBA 11/2008
1	LigandsIBA 11/2008
1	Glucose (Dextrose)FDA LinkGeneric 11/2008

Therapy/Procedure

7	Immunotherapy 01/2023 - 12/2017
6	Therapeutics 05/2023 - 11/2011
2	Transplantation 01/2023 - 01/2020
1	Anesthesia 06/2012
1	Induced Hypothermia 06/2012